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Topiramate attenuates self-injurious behaviour in Prader-Willi Syndr=
ome.
Shapira NA, Lessig MC, Murphy TK, Driscoll DJ, Goodman WK.
Department of Psychiatry, Evelyn F and William L McKnig=
ht
Brain Institute of the University of Florida, Gainsville 32610-0256, USA.
shapira@psych.med.ufl.edu
Self-injurious behaviour (SIB), most notably skin picking, has been describ=
ed
by various terms in the literature ranging from neurotic/psychogenic
excoriations to compulsive/pathological skin picking. Prader-Willi Syndrome
(PWS) is a neurogenetic multisystem disorder characterized by infantile
hypotonia, mental retardation, short stature, hypogonadism, dysmorphic
features, and hyperphagia with a high risk of obesity. Psychiatric
manifestations include SIBs in the form of skin picking, nail biting and re=
ctal
gouging. Topiramate is a novel anti-epileptic medication without significant
liability of weight gain. There are no published reports of topiramate being
utilized in PWS or SIB. We report attenuation of SIB with resultant lesion
healing in three PWS adults treated with topiramate in an 8-wk open-label
trial. Although our findings should be treated with caution, they suggest t=
hat
double-blind or cross-over studies with topiramate are warranted to establi=
sh
the possible role of topiramate in attenuating SIB in PWS and other disorde=
rs
that involve SIB.
Publication Types: =
· =
Case
Reports
· =
Clinical
Trial
PMID: 12135538 [PubMed - indexed for MEDLINE]
http://www.ncbi.nlm.nih.gov/entrez/=
query.fcgi?cmd=3DRetrieve&db=3DPubMed&list_uids=3D12135538&dopt=
=3DAbstract
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