The University of Warwick: News, Media and = Events

From: Subject: The University of Warwick: News, Media and Events Date: Tue, 18 May 2004 22:45:56 -0300 MIME-Version: 1.0 Content-Type: multipart/related; boundary="----=_NextPart_000_005B_01C43D29.E1DE4410"; type="text/html" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2739.300 This is a multi-part message in MIME format. ------=_NextPart_000_005B_01C43D29.E1DE4410 Content-Type: text/html; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.newsandevents.warwick.ac.uk/index.cfm?page=pressrelease&id=1875 The University of Warwick: News, Media and = Events

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Fat Fighting Undermined By Over = Active=20 Eating Pacemaker

Date = :10/05/2004

Type : Press = Release

=20

Dr=20 Dave = Spanswick

Researchers at the University of = Warwick have=20 for the first time been able to detail how = and why=20 specific neurons in the brain control the = hunger=20 response. They have revealed a set of = pacemaker=20 nerve cells in the brain that appear to = underlie=20 the drive to feed which itself feeds on a = complex=20 web of signals. The level of complexity = they have=20 found is such that the system could be = much more=20 at risk of serious repercussions from a = single=20 error in how those signals are processed = than=20 anyone had previously thought. Any number = of a=20 range of errors could lead to over = activity of=20 these pacemaker cells and explain why many = people=20 find difficulty in eating less.

In the research, published in the May = Issue of=20 Nature Neuroscience, Dr David Spanswick = and his=20 research team in the University of = Warwick=92s=20 Department of Biological Sciences, looked = at a=20 part of the brain called the hypothalamic = arcuate=20 nucleus which was known to deal with = hunger and=20 satiety signals but how it achieves this = is poorly=20 understood. The University of Warwick team = have=20 identified very specific neurons that act = as=20 feeding =93pacemakers=94.

This specific group of neurons- which = they have=20 dubbed the =93ARC pacemaker=94 produce = regular bursts=20 of electrical activity. However these = cells=20 integrate and process a wide variety of = signals=20 indicating the energy needs of the body = signals=20 most often transmitted by the use of = chemical=20 messengers such as hormones like ghrelin, = released=20 from the gut and leptin from fat cells. = The=20 combination of these signals and their = integration=20 by the ARC pacemaker is such a finely = balanced=20 mechanism that one small error or mutation = leading=20 to any inappropriate communication in = these=20 pathways could produce a significant = untoward=20 affect on human eating or feeding = patterns.

The high number of potential ways that = this=20 delicately balanced hunger pacemaker can = go wrong=20 could explain why many overweight people = are=20 unable to address their weight problems by = a=20 combination of diet and exercise. In the = past=20 people with a weight problem have faced = scepticism=20 and doubts as to how hard they were really = trying=20 to stick to diet and exercise regimes. = This=20 research shows that there may indeed be = very good=20 reasons why they seem unable to solve = their weight=20 problems simply by employing the usual = methods, -=20 eating less may be a more difficult and=20 complicated problem than we currently=20 anticipate.

Full text of research paper on Nature=20 Neuroscience: web=20 site

For further information please = contact:=20

Dr David Spanswick
Dept of = Biological=20 Sciences
University of Warwick
Tel: = 024 76=20 574182
D.C.Spanswick@warwick.ac.uk

Further Information

Note for Editors: This research = was=20 supported by the Biotechnology and = Biological=20 Sciences Research Council (BBSRC), The = Foundation=20 for Prader-Willi Research (USA) and = British Heart=20 Foundation=20 = (BHF).

You may like to see:=20 =

Communication= s=20 Office

Old=20 version of the press release web = site

Or contact:

Peter Dunn
Press Officer
University of=20 Warwick
Tel: 024 7652 3708
Mob: 07767=20 655860
Email: p.j.dunn@warwick.ac.uk=20

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=A9 The University of Warwick, = 2004. All=20 rights reserved

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